- Sand Gravel & Aggregate, Louisa
- Sandwich Shop Restaurants, Louisa
- Satellite TV Service, Louisa
- Secondary Schools, Louisa
- Secretarial & Court Reporting Services, Louisa
- Security & Commodity Brokers, Louisa
- Senior Citizens Service & Health Organizations, Louisa
- Shoe Stores, Louisa - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Louisa
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- Signs, Louisa
- Snacks & Desserts, Louisa
- Social Services & Welfare, Louisa
- Specialty Stores, Louisa
- Sporting Goods Stores, Louisa
- Staffing & Support Services, Louisa
- State Government, Louisa
- Substance Abuse Clinics, Louisa - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Swimming Pools, Louisa
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