- Radiator Coolant & Solvents, Middlesboro - Engine Coolant
- Radio & Television Repair Shops , Middlesboro - TV Repair
- Radio Stations & Broadcasting Companies, Middlesboro
- Ready Mix Concrete, Middlesboro - Concrete Suppliers, Dealers & Company
- Real Estate, Middlesboro - Agent, Broker & Companies
- Real Estate Agent - Property Lessors, Middlesboro
- Real Estate Attorneys & Lawyers, Middlesboro
- Real Estate Developers, Middlesboro
- Real Estate Services, Middlesboro
- Recycling Drop-Off Centers, Middlesboro
- Recycling Scrap & Waste Materials, Middlesboro - Scrap Metal, etc
- Refrigeration Repair & Service, Middlesboro - Ac, Freezer, Refrigerator Repair
- Rehabilitation Centers, Products & Services, Middlesboro
- Rehabilitation Specialists, Middlesboro
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- Religious Education, Middlesboro
- Religious Organizations, Middlesboro
- Rental & Leasing Business Equipment, Middlesboro
- Repair Services, Middlesboro
- Research & Development Bureaus, Middlesboro - Commercial, Economic, Sociological & Educational Research
- Research Services, Middlesboro
- Residential, Middlesboro
- Residential Apartments, Middlesboro
- Residential Care Facilities, Middlesboro
- Restaurants - Breakfast Brunch Lunch, Middlesboro
- Restaurants/Food & Dining, Middlesboro
- Retail Book Stores, Middlesboro
- Roofing Materials & Supplies, Middlesboro
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