- Salvage Yards, Junk Yards & Wrecker Service, Shepherdsville
- Sand Gravel & Aggregate, Shepherdsville
- Sandblasting, Shepherdsville - General Contractors
- Sandwich Shop Restaurants, Shepherdsville
- Satellite & Cable TV Equipment & Systems, Shepherdsville
- Satellite Dish Antennas & Equipment Dealers, Shepherdsville
- Satellite TV Service, Shepherdsville
- Savings & Loan Associations, Shepherdsville
- Savings Banks, Shepherdsville
- Scrap & Waste Machinery, Shepherdsville
- Scrap & Waste Materials, Shepherdsville
- Screen Printing, Shepherdsville
- Seafood Restaurants, Shepherdsville
- Secondary Schools, Shepherdsville
- Secretarial & Court Reporting Services, Shepherdsville
- Security & Surveillance System & Equipment, Shepherdsville
- Security Alarm Systems - Home & Business, Shepherdsville
- Security Brokers & Dealers, Shepherdsville
- Security Control Systems & Monitoring, Shepherdsville - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, Shepherdsville
- Senior Citizens Service & Health Organizations, Shepherdsville
- Septic Tank Installation & Repair, Shepherdsville - Septic Systems
- Septic Tank Pumping & Cleaning, Shepherdsville - Septic Systems
- Septic Tanks & Septic Systems Contractors, Shepherdsville - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, Shepherdsville - Wholesale, Dealers & Suppliers
- Service Establishment Supplies & Equipment, Shepherdsville
- Sewer & Drain Cleaning & Repair, Shepherdsville - Drain Cleaner & Installation Services
- Shoe Stores, Shepherdsville - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Shepherdsville
- Siding Contractors, Shepherdsville - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Shepherdsville
- Silicones & Silicone Products, Shepherdsville
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- Snacks & Desserts, Shepherdsville
- Snow Removal Services, Shepherdsville - Snow Plow Service
- Social Clubs & Organizations, Shepherdsville
- Social Services & Welfare, Shepherdsville
- Societies & Foundation Associations, Shepherdsville
- Southern Style Restaurants, Shepherdsville
- Special Education & Care, Shepherdsville
- Special Events & Party Supply Rental, Shepherdsville
- Special Interest Schools Or Instruction, Shepherdsville
- Specialty Animal Services, Shepherdsville
- Specialty Communication Companies & Services, Shepherdsville
- Specialty Goods Storage, Shepherdsville
- Specialty Stores, Shepherdsville
- Speech & Hearing Specialists, Shepherdsville
- Speech Pathologists, Shepherdsville - Speech & Language Therapy
- Sporting Goods Stores, Shepherdsville
- Sports Medicine, Shepherdsville - Doctors, Physicians & Surgeons
- Sprinkler Alarm Systems, Shepherdsville - Fire Sprinkler Systems
- Staffing & Support Services, Shepherdsville
- State Government, Shepherdsville
- Steak House Restaurants, Shepherdsville
- Steel Manufacturers, Shepherdsville
- Stock & Bond Brokers & Dealers, Shepherdsville
- Stocks & Bond Brokers, Shepherdsville
- Stone & Rock Quarry, Shepherdsville - Gravel Pit, Shale, Granite, Limestone, Crushed Rock, etc
- Storage Trailers & Containers, Shepherdsville
- Stoves & Furnace Equipment, Shepherdsville - Fittings & Repair Parts
- Surveyor Services, Shepherdsville - Surveying Service
- Sushi Restaurants, Shepherdsville
- Swimming Lessons & Classes, Shepherdsville
- Swimming Pool, Sauna & Spa Contractors, Shepherdsville
- Swimming Pools Contractors, Shepherdsville - Install Inground - Above Ground Pools
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