- Salvage Yards, Tompkinsville - Auto, Motorcycle, Boat, Trucks, etc
- Sandwich Shop Restaurants, Tompkinsville
- Savings Banks, Tompkinsville
- Sawmill & Planing Mills, Tompkinsville
- Sawmill Supplies & Equipment Repair, Tompkinsville
- Seafood Restaurants, Tompkinsville
- Secondary Schools, Tompkinsville
- Senior Citizens Housing, Tompkinsville
- Senior Citizens Service & Health Organizations, Tompkinsville
- Shopping & Shopping Services, Tompkinsville
- Siding Materials, Tompkinsville
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- Small Appliances, Tompkinsville
- Social Security And Disability Attorneys & Lawyers, Tompkinsville
- Social Security And Disability Lawyers & Attorneys, Tompkinsville
- Social Services & Welfare, Tompkinsville
- Societies & Foundation Associations, Tompkinsville
- Special Interest Schools Or Instruction, Tompkinsville
- Specialty Stores, Tompkinsville
- Sporting Goods Stores, Tompkinsville
- State Government, Tompkinsville
- Stone & Rock Quarry, Tompkinsville - Gravel Pit, Shale, Granite, Limestone, Crushed Rock, etc
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