- Safe & Vault, Hopkinsville
- Safety & Security Systems & Consultants, Hopkinsville
- Salvage Yards, Hopkinsville - Auto, Motorcycle, Boat, Trucks, etc
- Salvation Army, Hopkinsville
- Sandwich Shop Restaurants, Hopkinsville
- Satellite Communication Downlinking & Uplinking, Hopkinsville
- Satellite Descrambling & Programming Service, Hopkinsville
- Satellite Dish Antennas & Equipment Dealers, Hopkinsville
- Satellite TV Service, Hopkinsville
- Savings Banks, Hopkinsville
- Sawmill, Paper & Woodworking Supplies, Machinery & Equipment, Hopkinsville
- Scaffolding & Aerial Lifts, Hopkinsville
- School - Christian, Hopkinsville
- Scrap & Waste Materials, Hopkinsville
- Screen Houses, Hopkinsville
- Screen Printing, Hopkinsville
- Seafood Restaurants, Hopkinsville
- Sealants Retail, Hopkinsville
- Secondary Schools, Hopkinsville
- Security & Surveillance System & Equipment, Hopkinsville
- Security Alarm Systems - Home & Business, Hopkinsville
- Security Brokers & Dealers, Hopkinsville
- Security Guard & Patrol Service, Hopkinsville - Bodyguard, Guard Dogs, Etc
- Security Services, Hopkinsville
- Senior Citizens Service & Health Organizations, Hopkinsville
- Septic Tank Pumping & Cleaning, Hopkinsville - Septic Systems
- Service & Gas Station Equipment & Services, Hopkinsville
- Sewer & Drain Cleaning & Repair, Hopkinsville - Drain Cleaner & Installation Services
- Sewing Machine Repair & Service, Hopkinsville
- Sewing Machines, Equipment & Supplies, Hopkinsville
- Sharpening Service, Hopkinsville
- Shock Absorber, Hopkinsville
- Shock Absorbers & Struts, Hopkinsville
- Shoe Stores, Hopkinsville - Mens, Womens & Kids Shoes
- Shooting & Target Ranges, Hopkinsville
- Shopping & Shopping Services, Hopkinsville
- Siding Contractors, Hopkinsville - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Siding Materials, Hopkinsville
- Signs, Hopkinsville
- Skating Rink & Hockey Operation Services, Hopkinsville
- Skin Care & Cosmetology Salons, Hopkinsville
- Skin Care Products & Treatments, Hopkinsville
- Sleep Disorders Treatment & Information Centers, Hopkinsville
- Small Appliances, Hopkinsville
- Small Business & Office Equipment Repair Services, Hopkinsville
- Smoothie Restaurants, Hopkinsville
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- Snack Foods, Hopkinsville
- Snacks & Desserts, Hopkinsville
- Social Security And Disability Attorneys & Lawyers, Hopkinsville
- Social Security And Disability Lawyers & Attorneys, Hopkinsville
- Social Security Counselors & Representatives, Hopkinsville
- Social Services & Welfare, Hopkinsville
- Societies & Foundation Associations, Hopkinsville
- Sod & Sodding Service, Hopkinsville
- Special Coatings, Hopkinsville - Protective Coatings
- Special Dies Tools Jigs & Fixtures Manufacturers, Hopkinsville
- Special Education & Care, Hopkinsville
- Special Interest Schools Or Instruction, Hopkinsville
- Specialty Animal Services, Hopkinsville
- Specialty Communication Companies & Services, Hopkinsville
- Specialty Goods Storage, Hopkinsville
- Specialty Stores, Hopkinsville
- Speech & Hearing Specialists, Hopkinsville
- Speech Pathologists, Hopkinsville - Speech & Language Therapy
- Sporting Goods Stores, Hopkinsville
- Sports Clubs, Hopkinsville
- Sports Medicine, Hopkinsville - Doctors, Physicians & Surgeons
- Sportswear Clothing Stores, Hopkinsville - Sports Clothes
- Spraying Booths & Equipment, Hopkinsville
- Staffing & Support Services, Hopkinsville
- State Government, Hopkinsville
- State Parks, Hopkinsville
- Steak House Restaurants, Hopkinsville
- Steel & Metal Goods, Hopkinsville - Steel Distributors
- Steel Manufacturers, Hopkinsville
- Steel Used, Hopkinsville
- Stock & Bond Brokers & Dealers, Hopkinsville
- Stocks & Bond Brokers, Hopkinsville
- Stone & Rock Quarry, Hopkinsville - Gravel Pit, Shale, Granite, Limestone, Crushed Rock, etc
- Stone Setting Contractors, Hopkinsville
- Storage Trailers & Containers, Hopkinsville
- Student Housing & Services, Hopkinsville
- Submarine Sandwich Restaurants, Hopkinsville
- Substance Abuse Clinics, Hopkinsville - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Sunrooms & Solarium Construction Contractors, Hopkinsville - Build & Repair
- Sunrooms, Greenhouses, Solariums & Atrium Builders, Hopkinsville - Build & Repair
- Surgical Hospitals, Hopkinsville - Surgical Centers
- Swimming Lessons & Classes, Hopkinsville
- Swimming Pool, Sauna & Spa Contractors, Hopkinsville
- Swimming Pools Contractors, Hopkinsville - Install Inground - Above Ground Pools
- Swimming Pools Supplies, Equipment & Accessories, Hopkinsville
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