- Dairy Products - Wholesale & Retail, Prestonsburg
- Dance Companies, Prestonsburg
- Day Spas, Prestonsburg
- Decorating & Designing Services, Prestonsburg
- Dental Bonding & Cosmetic Dentistry, Prestonsburg - Cosmetic Dentist & Tooth Bonding
- Dentists, Prestonsburg
- Department Stores, Prestonsburg
- Developmental Disabilities, Prestonsburg
- Developmentally Disabled Information & Services, Prestonsburg
- Dialysis Clinics, Prestonsburg - Kidney Dialysis Centers
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- Diesel, Prestonsburg - Engine Fuels, Oils & Lubricants
- Disabled Persons Assistive Services, Prestonsburg
- Disaster Preparedness Equipment & Supplies, Prestonsburg
- Discount Stores, Prestonsburg - Clothing, Grocery, Furniture, Etc
- Doctors, Physicians & Surgeons, Prestonsburg
- Drainage Contractors, Prestonsburg - Install & Repair Drainage Systems
- Drinking Establishments, Prestonsburg
- Drug Screening Services, Prestonsburg
- Dry Cleaning & Laundry, Prestonsburg - Dry Cleaners
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