- Cafe Restaurants, Simpsonville
- Candle Manufacturers, Simpsonville
- Candy, Nut & Confectionery Wholesale & Retail, Simpsonville - Candy Stores
- Car Detailing & Wash Service, Simpsonville - Auto Detailing
- Car Wash, Cleaning, Wax & Polish Service, Simpsonville
- Career & Vocational Counseling, Simpsonville
- Casual Dining Restaurants, Simpsonville
- Chicken Restaurants, Simpsonville
- Children's Clothing Stores, Simpsonville - Infant, Babies & Kids Clothing
- Chinese Restaurants, Simpsonville
- Chocolate & Cocoa, Simpsonville
- Christian Churches, Simpsonville
- Churches 1 Of 3, Simpsonville
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- Cigar, Cigarette & Tobacco Store & Supplies, Simpsonville
- City & County Administrative Agencies, Simpsonville
- City & County Government, Simpsonville
- Clothing Stores, Simpsonville - Clothes & Accessories
- Collection Agency Services, Simpsonville
- Communications Services, Simpsonville
- Community Services, Simpsonville
- Concrete Contractors, Simpsonville - Concrete Construction & Concrete Companies
- Construction, Simpsonville
- Consultants & Services, Simpsonville
- Convenience Stores, Simpsonville
- Cosmetics, Simpsonville
- Country Cooking Restaurants, Simpsonville
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