- Pants & Jeans, Simpsonville
- Paper & Cardboard Manufacturers, Simpsonville
- Parka Stores, Simpsonville - Anorak
- Passenger Vehicle Dealers, Simpsonville
- Personal Care, Simpsonville
- Personal Services, Simpsonville
- Pet Care Services, Simpsonville
- Pet Food & Supplies, Simpsonville
- Pet Grooming & Boarding, Simpsonville
- Pet Grooming & Boarding Services, Simpsonville
- Pet Shops & Supplies, Simpsonville
- Pets Stores & Pet Supplies , Simpsonville
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- Physician & Doctor Supplies & Equipment, Simpsonville - Surgical Supplies
- Pipeline Contractors, Simpsonville - Oil, Water & Gas Pipeline Companies - Installation & Repair
- Pizza Restaurant 1 Of 2, Simpsonville
- Plants, Trees, Flowers & Seeds, Simpsonville
- Plastic Mold Manufacturers, Simpsonville
- Plastic Molds & Plastic Processing, Simpsonville
- Plastic Products Manufacturers, Simpsonville
- Plumbers & Plumbing Contractors, Simpsonville - Installation, Repair & Replace Services
- Private Investigator & Consultants, Simpsonville
- Private Investigator & Detective Agency, Simpsonville
- Professional Services, Simpsonville
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